Life Sciences | Page 6 | Technology Licensing

Available Technologies by Category

Ribonucleotide-Capture Method Enables the mapping of precise-genome wide positions of rNMPs incorporated in genomic DNA Results in sensitive and specific identification and mapping of rNMPs Could be used for further understanding of the biological implication and consequences of rNMP incorporation in DNA	6522
A Method for Exhaustive CRISPR Off-Target Analysis Provides exhaustive genomic searches for off-target sites due to mismatches, deletions, and insertions Provides primers for experimental validation of predicted off-target sites Facilitates experimental testing using assays or deep sequencing of potential off-target sites given in the output	6478
Microfluidic Device for Cell Aggregates Control - Precise control over the cell culture environment High content assays – Multiple types of imaging-based assays can be done on the same sample, both during live culture and at end-point High throughput – Greater number of experiments	7720
Embedded Wireless Temperature Sensor for Orthopedic Implants Utilizes temperature as indication of deep tissue infection Deep tissue measurement vs. only reaching skin surface Non-invasive monitoring	7682
Real-Time Identification of Erroneous 3D Print Designs Real-time automated monitoring of 3D printing process Addresses potential threats of malicious manipulations	7636
Cancer Diagnosis Using Nanotechnology Can be used with a simple microscope More sensitive and cost-effective Non-toxic	3424
Microfluidic Droplet for Drug Delivery and Therapeutic Applications Viable, cellular micro-environments requiring precise control are achieved using hydrogel microspheres with diameter sizes ranging from 10-1000 micrometers A protective, semi-permeable capsule encases the cells and biomolecules Release rates of encapsulated biomolecules or drugs are controlled by adjusting the polymer parameters used to fabricate hydrogel microspheres	6467
Disease Progression Modeling Accurate - Provides continuous time modeling, which is more appropriate for medical data due to patients being monitored at irregular intervals Multipurpose - Could be used for disease staging, characteristic progression pattern discovery, prediction of the future state of disease, fast local progression detection, and to enable understanding of disease progression	6466
Recyclable and Reusable Co-Salen Complexes for Catalytic Use Recyclability Retention of activity and selectivity Ease of separation from reaction product	3409
New Imaging Tool to Compare Healthy and Diseased Cells Discrimination between healthy & diseased cell biology Personalized medicine – specific treatment for an individual Diagnosis of a disease prior to symptoms	6458
Assistive Stairs Utilizing Energy-Recycling Technology ERAS are the only energy-recycling device tailored for assistance during stair movement. The modular design of ERAS allow for quick and easy installation (and removal, if necessary) on top of an existing staircase without expensive remodeling. The low-cost and low-power design allow ERAS to be more affordable and practical to people with limited financial resources.	7596
Synthetic Nano-Antibodies for Immunotherapy Cheaper and faster to manufacture- production only involves synthesis of ligands, nanoparticles, and nano-antibodies; it does not involve cell-lines or animal work More effective- better accumulation and penetration is achieved due to the nanoparticle design Better for patients- dosage to achieve therapeutic efficacy is reduced and can lower the price, duration, and frequency of treatment	7554
Oriented NanoFilament Construct for Nerve Regeneration Provides directional cues for cell and tissue regeneration Eliminates donor site morbidity associated by allografts Easily manufactured	3404
PUPS: Pressure Ulcer Prevention System Enhanced quality of care: Patients are less likely to develop a hospital-acquired infection Lower cost: Minimizes costs from “never events” such as pressure ulcers	7541
Biopolymer Fabricated Materials for Biomaterials Novelty – first technology that enables the formation of biopolymer brushes at interfaces of any thickness Incredibly biocompatible – hyaluronan has many salient features such as being non-fouling, non-immunogenic, and viscoelastic that make it a common polymer used in biomedical applications Potential for regenerative technology – further applied in regenerative interface technology research	7535
Multiple Degree-of-Freedom Micro-Scale Guidewire Lays the foundation for developing the world’s smallest bidirectional motion capable, multi-DOF, mechanically actuated guidewire Achieves individual control of each degree-of-freedom Enables greater range of motion and steer ability at anywhere along the length of the guidewire compared to traditional active guidewires	7532
Smart Test Strip Enabled by Inkjet Printed Microfluids Cost effective manufacturing approach Eco Friendly Light-weight	7505
Rapid Antibiotic Susceptibility Test Relatable: Does not rely on genetic detection, making it more general and directly relatable to traditional ASTs used clinically Faster: Can perform ASTs in 1/8th of the time of current ASTs Improved accuracy: Decreases technician time and handling, improving accuracy and treatment	7492
Noncoding RNA Targets for RNA Interference Novel group of RNA interference targets with utility in basic research and practical applications Non-coding interference RNAs (nciRNAs) offer an efficient mechanism of mortality in eukaryotic cells Highly specific targeting of pests or pathogens	6432
Interfering RNA Production and Delivery Using Virus-Like Particles Inexpensive, rapid, adaptable, and reliable in vivo system for sequestering and packaging of iRNAs Flexible, for long or short, single-stranded or double-stranded iRNA of any sequence Efficiently delivers iRNA to biological targets; VLP-iRNAs are readily taken up by many cell types	6427
Method for Intracochlear and Vestibular Magnetic Stimulation Provides hearing- magnetic fields couple with auditory neurons to produce excitation perceived by the brain was a sound signal Better sound quality- more precise frequency resolution produces better sound quality More reliable signal and decreased sound quality degradation- intervening tissues between array and auditory neurons are no longer a carrier for signals, which will prevent attenuation signal interference	7485
Method for Clinical T-Cell Expansion Higher cell densities Protection from high shear production environments Reduced initial and operating cost	7434
Antibody Coated Nanoparticle Vaccines Enhance vaccine immunogenicity Prolong vaccine protection Reduce safety risks associated with pathogen-derived vaccine adjuvants	7403
Tongue Tracking System (TTS) for Speech Impairment, Diagnosis and Therapy Wireless technology for diagnosing speech and language impairments, providing audio-visual biofeedback for therapy and silent-speech interfacing Allows users to see the motion of the tongue and visualize their speech Helps overcome speech imprecision	6367
Antifolate Compound as Multi-Drug Resistant Pathogens Novel structure with high binding affinity for DHFR Demonstrated growth inhibition of numerous pathogens Demonstrated antibacterial activity for mulit-drug resistant strains of E. coli, methicillin-resistant S. aureus (MRSA), vancomycin-resistant E. faecalis & antifungal activity against amphotericin–resistant Candida albicans	6296
Hyper Resonance Wireless Power Transmission Increases power transfer efficiency for wireless devices Reduces power consumption Improves signal-to-noise ratio	6291
3D Printed Device for Tumor Cell Diagnostics Minimally invasive – potentially eliminates the need for invasive serial biopsies Cheaper – simple manufacturing process Disposable - size and materials allow for easy disposal	7346
Foot GO: The Foot Granular Orthosis Customizable: Can easily adjust fit and stiffness Simpler: Has potential to simplify the foot orthosis manufacturing process Re-conformable: Custom fit and stiffness can be readjusted multiple times for changing needs over time	7338
3D Optical Microscope Imaging System Versatile — Analyze several small scale samples Easy-to-use — Decoding of the 3D information is straightforward and involves only 2D digital image correlation (2D-DIC) calculations or other types of 2D displacement analysis Accurate — High measurement accuracy (sub-pixel accuracy of ~10)	6136
Wideband Data Transmission Using Pulse - Delay Modulation Faster: Provides higher data rate wireless transmission and reception Lower power: Reduces power consumption Stronger signals: Improves signal-to-noise ratio	6075
Magnesium Composites for Biomedical Implant Applications Biodegradable – Healing process is not compromised by a permanent implant device High Strength – Mechanical properties match those of the natural skeletal structure Reliable – Decreases failure during or after installation	6070
Small Molecule Binders of a Human Peptide for Therapeutic Use First discovery of small-molecules binding to the central catalytic domain of NGly1 Could be used to treat the inherited genetic disorder resulting from NGly1 deficiency	7306
Neuromodulation of Vagal Stimulation Enhances anti-inflammatory effects of vagus nerve stimulation Pairs electrical stimulation with kilohertz electrical stimulation nerve block to achieve directional stimulation Quick, reliable anti-inflammatory clinical effects	7275
Therapeutic Protein Nanoparticles Low cost and effective production method Maintains protein structure and enzymatic activity and maximizes the amount of protein to be delivered Preserves bioactivity	5979
Medical Tubing Solution for Bacteria Prevention Prevent various infections currently impacting patients due to bacteria formation on medical tubes. Solution that can be utilized with existing medical tubes. Does not leach any materials from the tubing surface.	7274
Prosthetic Anterior Cruciate Ligament Simpler - Simplifies the operation Safer - Prevents unnecessary damage and morbidity at a donor site Readily available - Obviate need for harvest procedure	5856
Surface Nanomodification by Microwave Hydrothermal Treatments Cost and Energy efficient- requires shorter times of surface modification with a lower concentration of solvents Less hazardous- lower concentrations of solvents decrease the negative environmental impact Versatile- though primarily related to biotechnology, this method can be applied in any industry requiring surface modification	5784
X-Ray Compton Scatter Imaging on Volumetric CT Systems Reduces radiation exposure in conventional imaging systems Enhances data acquired from VCT, CT, and X-ray imaging Applied to a wide range of VCT systems	5730
Multiplexed Analysis of Cells for Cancer Research Enables the evaluation of cell properties in a biomimetic three-dimensional microenvironment Mnimal disruption of cell-cell and cell-material interactions Multiplies the number of variables that can be analyzed without significantly increasing the time of analysis	7236
Polymer Wrapping of Single Wall Carbon Nanotubes Scalable – process can be easily scaled up to enable commercial applications Flexible – PMMA wrap can be applied through a variety of processing conditions Removable – helical wrap allows PMMA to be removed without damaging nanotube	7213

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