Life Sciences | Page 4 | Technology Licensing

Available Technologies by Category

Purification of Cell Mixtures Using Molecular Beacons Purified cardiomyocytes can be used to regenerate damaged cardiac tissue in vivo This method can be used to purify other types of stem cell derivatives It can also be used to develop pure laboratory cell cultures for pharmacologic testing and research	6463
A Screening Method to Detect Ovarian Cancer Early stage detection Highly accurate Minimally invasive	7028
Microfluidic Platform for Phase Separation of Aqueous Solutions Efficient workflow- sample removal and analysis can be performed without manual oversight Smaller sample size- less sample volume required alleviating dilution of low concentration solutions that is common in alternative sample preparation workflows Faster process- thermoelectric cooling can induce separation in a matter of seconds with precision and tunability	8247
Compositions & Methods for Using NADH Oxidases Biocatalysis is used in many industries including food, bioenergy, & pharmaceutical. Recycling cofactors is necessary to control costs of biocatalysis reactions. NADH oxidases convert NADH to NAD+, a major cofactor involved in biocatalysis.	4698
Hydrogel Surfaces for Modulation of Cell Secretory Activity Multiple formulations – set of hydrogel formulations to control the secretory behavior of cells Customizable – hydrogels can be tailored to exhibit a range of mechanical and biochemical properties: Mechanical properties controlled by length and concentration of polymers, concentration of free radical initiators, curing time Biochemical properties include what peptide, lipid, carbohydrate or other moieties are incorporated into the hydrogel network. Can be formed as flat surfaces or three dimensional matrices	8016
Devices, Systems and Methods for Ultrafast Optical Applications Enables the design of an ultrafast all-optical shutter technology in the visible spectral range Amplifies the strong and ultrafast nonlinear optical response of noble metal thin films Requires lower pump energies than conventional nonlinear optical materials or devices	6221
Method for Treatment of Pathologies Fast - activity is immediate (within 2 hours) Easy to use - applied to nasal sprays or skin patches Safe – less immunogenic	7878
Fluorescence Microscopy with an Ideal sCMOS Camera Fast – produces fully quantitative sCMOS image restoration up to 100 times faster than the current state-of-the-art Accurate – produces fully quantitative sCMOS image restoration up to two orders of magnitude more accurate than the current state-of-the-art Improved features – allows a broad range of imaging techniques without compromising data reliability	8098
Nanocrystalline Glass Ceramic Scintillators Cheaper – Can be easily fabricated on a large scale Efficient – High luminescence efficiency and light output Compact – Greater portability	5509
Segmenting Stroke-Like Structures in Images Computationally efficient User-friendly Operator guidance — correction of errors	4096
Fibrin "Knob" Therapeutics Simple method Robust production Innate therapeutic potential	4021
Vortex Generators for Prosthetic Heart Valves Unique- biocompatible and customizable vortex generators Lower-cost- technology of quick molding fabrication Reduced TAT- vortex generators implanted in BMHVs have shown to reduce TAT by greater than 42%	3968
Biomolecular Coating for Implants Simple, one-step surface modification without chemical cross-linking agents Modification at the time of surgery in the operation room Straight forward sterilization	3967
Fast Microscale Actuators for Probe Microscopy Enables fast and parallel actuation with integrated electrostatic actuators and built-in optical displacement sensors Accurate force measurement with nanometer resolution in parallel single-molecule mechanics experiments Novel FIRAT structures for high speed AFM imaging in liquid environments	3916
Annuloplasty Ring & Methods for Tricuspid Valve Repair Specificity- aligns with specific landmarks only found on the tricuspid annulus Unique- attains an anterior, posterior, and septal segment that conform to the anterior, posterior, and septal sections of the native tricuspid annulus Regulatory- adjustable annuloplasty ring, which facilitates independent control over individual leaflets.	4240
New Methods of Fabrication for Biosensor Arrays Low manufacturing and operating cost Compatible with multiple standard electrochemical techniques Can be used with CMOS detection chips with multiple chemical detection and/or actuation channels or sites	4231
Piezoelectric Nanowire Based Hearing Aids Smaller size More power efficient	4222
Fluid Management System for Hemofiltration Compact- size addresses concern of restricted bed-side space Age-friendly- potential use in any age group, from newborns to adults	4209
Method for Imaging Mass Spectrometry Precise – Method allows for automatic, precise control of molecule deposition Scalable – Deposition method can be done on large or multiple samples Solvent-Free – Improved imaging quality by eliminating solvent in deposition	4202
Translating Sound into Soft Touch for Haptic Devices Low cost: Uses components that are less expensive than other high-tech options Better response: Responds more quickly and more refined/granular than existing products with slow and/or coarse responsiveness Enhanced performance: Achieves a silent, smoother, pulse-like response rather than an unpleasant push or buzz	5433
Click Hydrogel for Re-Synostosis Therapy Provides a novel delivery vehicle for proteins or other factors for correction of craniosynostosis. Spontaneously polymerizes without producing free radicals. Polymerization can safely take place in-vivo. Allows for tunable mechanical properties and compound release kinetics.	5430
Therapeutic Compounds for Prostate Cancer Treatment Prostate specific: This technology is a targeted approach for androgen receptor malignancies. More effective: It offers a new treatment for tumors that have progressed to the hormone refractory stage. Less toxic: Compounds are highly selective for targeted receptors.	5394
KIDSCRRT – A Device for Continuous Renal Replacement Therapy in Children Pediatric-friendly- elimination of existing application of adult CRRT devices for pediatric care Improved accuracy- novel pump and control system design complete with offset loop and fluid balance system Versatile- easily integrated with other extracorporeal therapies	5363
Alveolar Breath Separation and Collection Device Simple: this device has fewer components than prior devices Inexpensive: this device is less expensive than previous devices due to its simpler design	4734
Patterning of Superhydrophobic Paper Surfaces Versatile – allows for flexibility of paper and any array of “sticky” dots and lines Simpler – space saving alternative to three-dimensional microfluidic products Cheaper – made using paper and simple application process for “sticky” regions	4729
Periodic Arrays for Frequency-Based Beam Steering Avoids individual control of array components Reduced cost, smaller design equipment	4716
System for Bone Regeneration Provides superior retention and release of osteoinductive protein Reduces necessary dose of osteoinductive protein Reduced cost of procedure	4660
Wireless Implantable Neural Recording Wide wireless bandwidth Small sized wireless link system (3.3 x 3.0 mm-sq) Low power consumption (~5.6mW)	4654
Improved AZA-peptide Epoxides Versatile: able to treat multiple diseases Can be administered with or without other protease inhibitors	3738
Method for Packaging Advanced Sensors and Electronics High volume — device can be used for simultaneous sensing of thousands of proteins or nucleic acid sequences Cheaper — utilizes low cost wafer-scale semiconductor manufacturing technologies Versatile — can be used for many chemical and biochemical sensors	4514
Fluorescent Nanoprobes for Live-Cell RNA Imaging Sensitive — can image single molecules with multiple emission wavelengths Fast — probe is multivalent and bind to RNA in less than 10 minutes Low cost — the alternative dual-label probes are more expensive	4513
Replaceable Heart Valve Prosthesis Repeatable- method may be repeated multiple times Versatile- mechanism may substitute more than one valve Lower-cost	3692
Method for Minimally Invasive Heart Valve Procedures Minimally invasive: heart valve repair system breakdown allows for a smoother process Futuristic: eliminates the need for cardiopulmonary bypass Reduced risk: intends a lower mortality rate during procedure	4483
Core-Shell Nanogel Cellular Delivery Vehicles Delivery of a broad range of various materials to cells Higher payloads and faster and more sustained RNA interference than non-targeted commercial siRNA delivery vehicle Less toxic than commercial liposomal formulations	4480
Method to Control the Annular Septal-Lateral Diameter of a Valve Minimally invasive- tools for SLAC deployed endovascularly, percutaneously, or thorocoscopically through a catheter Effective- reduces the septal-lateral diameter on the mitral valve Biocompatible- provides an anchoring system for anchoring a minimally invasively deployed annuloplasty ring	3690
Carbon Nanotube Electrode Array for Neural Prosthetics Densely packed CNT arrays allow for better bio-incorporation, prevention of glial scarring, chronic inflammation, and neuronal cell loss Readily functionalized to promote neuronal growth and tissue-electrode adhesion, enhancing electrode performance and quality of read-out signals Inherent mechanical stiffness enhances the rigidity of adjacent CNTs preventing buckling as in other high-aspect probe systems.	4434
Reduced Cyanine Dyes Simple Synthesis - Easy one-step synthesis from commercially available cyanine dyes Dependable - Exceptional sensitivity Versatile - High stability and wide range wavelength tunability	4430
Chemically Resolved Microscopy Using Microplasma Discharges Can be operated under ambient temperature and pressure Higher chemical and spatial resolution than currently exists Has the ability to pair mass spectrometry to microscopy	4340
Cell-Free Biomaterial for Tissue Regeneration and Repair Simple — does not require difficult or extensive preparation Regenerative — provides unique molecular cues similar to early embryogenesis, enabling directing of cell differentiation and tissue morphogenesis Compatible and customizable — can be tailored for specific tissue applications by directing the differentiation of the ES cells prior to acellularization	3662
Portable Gage for Pressure Ulcer Detection Compact/light weight Precise Inexpensive to manufacture	4292

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