Life Sciences | Page 3 | Technology Licensing

Available Technologies by Category

High-Tech Infant Suit for Earlier Detection of Cerebral Palsy Advanced: May allow for earlier detection of motor dysfunctions in order to begin therapeutic interventions as soon as possible Robust: Collects data from three limb segments on the leg for a multifaceted assessment Long-lasting: Uses one power source with regulated voltage in order to prolong the use of the device	7949
LoCHAid: An Ultra-Low-Cost and Self-Fitting Hearing Aid Low cost: Uses widely available components that cost 98 cents when purchased in bulk quantities User friendly: Easier to fit—and keep track of—than conventional behind- and in-the-ear hearing aids Accessible: Designed for easy manufacture and repair in locations where conventional hearing aids are priced beyond the reach of most citizens	7876
Facilitating Ultrasound Penetration of the Skull for Diagnosis and Treatment Portable: Designed to enable imaging of the brain via small, mobile ultrasound devices, which may offer greater convenience compared with MRI and CT machines Affordable: May be a lower cost modality compared with leading techniques, such as MRI, CT, or positron emission tomography (PET) Robust: Demonstrates energy transmission through the skull on par with that of an aqueous medium in preliminary testing	8340
Near-Real-Time Positioning for Instruments and Tools in Magnetic Resonance Elastography (MRE) and Imaging (MRI) Precise: Extremely precise positioning mechanism enables orientation and control capable of sub-millimeter motions within the MR environment Rapid: Significantly speeds up procedure time over standard MRI and offers wavefield images in near real time High resolution: Uses high-frequency actuation to enable imaging of small, geometrically difficult targets	8412
A Partial-Hand Prosthesis Simulator Specific: Designed to maintain limb length by placing artificial fingers in positions similar to where they would be in an intact hand performing grasping actions (rather than extending the length of the limb as many prostheses do) User friendly: Features rubber-capped fingertips that may provide a more lifelike representation of grasp and enhance usability Nuanced: Designed to limit tactile sensation and feedback from immobilized fingers, which may allow better evaluation of how the device is functioning for the patient in comparison to an actual prosthesis	8534
Portable Multi-Parameter Cancer Diagnostic Tool Powerful: Simultaneously measures multiple tissue parameters to determine electro-thermo-mechanical properties Disposable: Uses single-use biochip components to eliminate cross-contamination Versatile: Uses a variety of other micromotion-capable actuators and extends to other manufacturing techniques and different length scales	7619
Next-Generation Custom-Fit Reusable Mask for Respiratory Protection Aims to eliminate fit-testing: Designed to remove the expensive and time-consuming federal (i.e., OSHA) mandate for annual fit-testing for workplace use Improved fit: Adapts to fit specific facial features, increasing comfort and enhancing efficacy and potentially eliminating face-seal leakage to enhance performance Reusable: Withstands cleaning and decontamination	6635
Vest-Style Device Assists Ventilation and Perfusion (V/Q) to Help Prevent Respiratory Failure Powerful: Designed to optimize oxygenation for patients in acute hypoxic respiratory failure Supportive therapy: Non-invasively complements mechanical ventilator support Low cost: Significantly less expensive than technologies that increase oxygenation (e.g., ventilators, oxygen systems)	8529
Novel Crosslinked Hydrogel Improves Efficacy and Side Effects of Cancer Treatment Versatile: Can integrate with all types of immune checkpoint blockade antibodies and respond to various types of cancers Improved tolerability via local delivery: Limits side effects on nonmalignant tissues and organs—a challenge of other immunotherapies Innovative: Leverages the body’s natural immune response to reduce the likelihood of cancer recurrence	8505
Novel Pharmaceutical Compounds Based on Tumor-Selective KDM Inhibitors Selective: Can be used to target specific types of tumors Proven efficacy in vitro: Can be used to inhibit proliferation of cells (e.g., cancer or tumor cells), reducing tumor burden, inhibiting tumor growth, or both Enhanced potency: Displayed a 65-fold increase in cytotoxic potency against tested triple negative breast cancer cell lines	7880
Novel Polymer Hybrid Improves Stability of Implantable Devices Strong: Provides structural stability and enhanced cellular adhesion for implant materials Biocompatible: Reduces the risk for complications that could arise with the use of chemical components Customizable: Permits easy incorporation of various nanomaterials to fine-tune devices to meet patient needs	8449
Powered Bilateral Knee Exoskeleton for Rehabilitation of Children and Adults Lightweight: Uses one of the lightest available electromechanical actuators—just 0.5 kg—along with a mere 1.5 kg for the exoskeleton assembly Back-drivable: Lowers the mechanical effort involved in back driving with a single-stage actuator Efficient: Reduces battery consumption compared with existing systems	8369
Multi-Functional Sparse Phased Arrays for Guiding Focused Ultrasound Therapies Robust: Provides sensitivity of detection down to a single microbubble for FUS-induced microbubble activity Precise: Offers broadband B-mode imaging capabilities to improve workflow and efficacy of FUS-based therapies Scalable: Enables the formation of large CMUT arrays and subarrays with appropriate element spacing	8493
Inverted Organoids for Breast Cancer and Other Invasion Studies Innovative: Serves as a convenient platform for studying the invasive abilities of breast cancer cells Stable: Enables formation of large inverted organoids where the basement membrane forms on the interior surface alongside a breast cell line epithelium Flexible: Allows for long-term studies of at least 25 days due to the robust maintenance of the inverted orientation	8460
Polymer-Based Removal of Pollutants from Contact Lenses Effective: Removes large-particle pollutants as effectively as traditional cleaning solutions, and removes smaller pollutants and microplastics with significantly higher efficacy Robust: Utilizes an elastic polymer that enables contact force between two elastic materials to do the work of removing particles of any size Safe: Eliminates the need for soaking and rubbing removal methods that may tear or damage contact lenses	8398
Assessment of Soluble Cancer Biomarkers for Focused Ultrasound Therapy Simple: Avoids reliance on magnetic resonance imaging (MRI)-based methods of monitoring and optimizing FUS therapy Safe: Relies on a small amount of fluid collected before/after FUS-targeted drug delivery Robust: Enables a range of new therapeutic interventions for cancerous tumors as well as both delivery and monitoring/optimizing of those therapies	8473
Streamlined Hematology Analysis for Point-of-Care Settings Streamlined: Enables testing in point-of-care settings without complex procedures and specially trained personnel Highly accurate: Offers a spatial resolution higher than current methods due to the shorter wavelength of UV light Cost-effective: Saves on reagents, complex equipment costs, and time-intensive processes without compromising diagnostic quality	8303
Technique Improves Printing Quality for 3D Nanoprinting High-performance: Enables a powerful process for high-throughput 3D printing of micro- and nanoscale structures Efficient: Reduces defects during printing to improve yield and decrease excess printing commonly observed with FP-TPL Improved: Broadens the applicability of FP-TPL to printing of functional micro- and nanoscale structures	8478
Super-Absorbent Polymer (SAP) Beads for Collection of Biofluid Samples Fast: Accommodates preloading of specimen collection tubes and completes absorption of analytical targets within a few minutes of fluid collection Low cost: Employs economical materials and eliminates the need for refrigeration of samples while also lowering the weight of samples for transport Easy to use: Avoids the need for filtration, centrifugation, or pipetting and the associated equipment for such tasks	7907
Novel Chemical Compounds Support Excess Copper Removal in Biological Systems Powerful: Displays an affinity for copper that is unprecedented among synthetic ligands, with a complex stability constant of logK = 20.0 Specific: Functions without interference by other metals in the body Effective: Possesses a strong copper coordinating ability, even in the complex chemical environments of different biological systems	8151
Airy-beam Tomographic Microscopy for Biological Imaging Streamlined: Offers a scan-free method of obtaining 3D-resolution images Volumetric imaging: Generates and resolves images of tissues and cells in the 3D space High resolution and image depth: Provides 3D diffraction-limited resolution	8381
A Semiconductor Particle Detector Based on Work Function Modulation Small: Can be used as a portable radiation detector Versatile: Can be implemented in current particle detectors for accuracy testing and experimental verification Scalable: Offers the potential to be used in creating an array of devices for implementation in larger research experiments	8410
High-Precision Cell Membrane Tracking for Automated Electrophysiology Highly accurate: Overcomes the challenges of tissue interference and movement for precise membrane tracking that can be used for automation Instantaneous: Surpasses earlier attempts at automating this process by effectively identifying and tracking cell boundaries in real time High fidelity: Operates efficiently and precisely even in dynamic, high-interference environments	7467
Voice-Activated Robotic Exoskeleton for Rehabilitation and Assistance Voice-activated movement controlled by the patient Integrated smartphone application to recommend exercises and schedules Quantitative performance metrics and analysis sent to the physical therapist	8130
Ultra-High Resolution Multimodal Imaging System Integrative perspective imaging - topological and chemical imaging of complex biological samples and heterogeneous nanomaterial interfaces with sub-micrometric resolution Improved spatial resolution - system provides chemical imaging resolution of ~ 250 nm and electron microscopy topological resolution of ~ 50 nm. Accuracy in analytics - analysis at the level of a single cell or with subcellular resolution has been seen as a next frontier in innovative approaches to discovery	8300
2D Array Device Simple – does not require microstructure fabrication or periphery equipment, such as pressure-driven pumps to operate Unique – loading method enables rapid sample loading and high-percentage sample isolation simultaneously Cheaper – improvements in efficiency and robustness reduce complexity and overhead expenses	8253
Disposable Impedance Biosensor for Cell Manufacturing Multi-point measurements- provide tempo-spatial profiles of culture attributes and can print a wide range of conductive and insulating materials on both rigid and flexible substrates with non-planar surfaces Wireless - collects the signal wirelessly via printed antennas to simplify the integration to different types of existing bioreactor technologies Safe - system does not apply contact, and minimizes any chance of harm or contamination to affect the cell culture	8270
Equipment-Free Quantification in Point-of-Care Diagnostic Assays Field-deployable robustness: uses reference reactions to accurately measure biomarker levels without expensive or cumbersome equipment Lower cost: quantification does not require expensive technology	7992
3D Light-Field Endoscopy Using a Gradient Index Lens Array Measurements: system achieves 'true quantitative' 3D information Imaging and visualization: system brings a great potential for fast 3D quantitative imaging, visualization, and synthesis of the focal stacks Material: method is glass-free	8283
Precision Needle Positioning Robotic System for MRI Guided Injection Increased accuracy — robot capable of less than 100 micron accuracy Increased speed — faster targeting of injection locations	8246
Spatial Tracking of Catheters in Interventional MRI Increased safety — eradicates RF induced heating while providing position of catheters in the body during iMRI procedures Simultaneous measurements — offers temperature measurements, orientation, and other parameters	7952
Guided Injection of Charged Cargo for Intracellular Delivery Novelty – use of an electrically-charged liquid beam of electrospray Improved control – control of action on the scale of single cell/single pores Diversity – arbitrary diverse set of cargo	8275
Instrumented Ankle-foot Orthosis User friendly – fully wearable and portable Objective data – enhances patient outcomes	7547
Wireless Neurovascular Monitoring System Minimally invasive: minimal impact on hemodynamics (dynamics of blood flow) Flexible and stretchable: able to conform to complex vessel geometry Longer range: improved wireless detection range	7908
Water-Soluble Mold for Sample Analysis Inexpensive: difference in materials used from existing practices, lowers manufacturing costs Universal adoption: no requirement of expensive cleanrooms facilities and associated personnel Environmentally: conscious- non-toxic process eliminates need for organic solvent and waste treatment	8138
MRI Compatible 3D Intracardaic Echography Catheter and System Provides real-time full-volume visualization of cardiac structures Enhances image guidance of complex catheter-based cardiovascular treatments Avoids radiation exposure	6491
A Technique for Integrating Photographs for Medical Imaging Examinations Prevents the application of incorrect patient identification at the time of medical image generation Allows the correlation of serial imaging studies by ensuring that all studies are from the same patient Avoids the generation of incorrect reports	6402
Constellation Diagrams to Model Biomolecules’ Electrostatic Properties Low computational cost – reduces algorithm run-time via reduction in complexity of computing molecular electrostatic properties Digitally encoded molecular electrostatic properties – utilizes orthogonal basis functions Visual toolsets- to analyze molecular electrostatic properties and generates 4D plots of molecular electrostatic properties	8245
Storage Media for Determining Optimal Respiratory Treatment Automatically determines optimal radiation therapy treatment phase Enables higher, more effective radiation dosage amounts Minimizes unnecessary radiation to normal surrounding tissues	6926
Self-Assembling Peptides for Cell and Notch-Ligand Delivery Hydrogels are biocompatible, easy to modify and biodegradable Could be applied in a more platform-like manner by incorporating other peptides to repair cardiac or other tissues The peptide sequence activates signaling of pathways improving the growth or replication of tissue or cells	6480

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