Life Sciences | Page 2 | Technology Licensing

Available Technologies by Category

Carbon Nanotube Electrode Array for Neural Prosthetics Densely packed CNT arrays allow for better bio-incorporation, prevention of glial scarring, chronic inflammation, and neuronal cell loss Readily functionalized to promote neuronal growth and tissue-electrode adhesion, enhancing electrode performance and quality of read-out signals Inherent mechanical stiffness enhances the rigidity of adjacent CNTs preventing buckling as in other high-aspect probe systems.	4434
Cell-Free Biomaterial for Tissue Regeneration and Repair Simple — does not require difficult or extensive preparation Regenerative — provides unique molecular cues similar to early embryogenesis, enabling directing of cell differentiation and tissue morphogenesis Compatible and customizable — can be tailored for specific tissue applications by directing the differentiation of the ES cells prior to acellularization	3662
Cell-free Biosensors to Detect Creatinine, Creatine, and Sarcosine Portable: This technology demonstrates the potential to develop point-of-care screening and monitoring, which is essential to expanding access to care worldwide, including to low- and middle-income countries. Inexpensive: CFE-based biosensors can cost as little as a few cents per test and could provide a low-cost alternative to current renal function monitoring and diagnosis, which currently involves laboratory visits, trained phlebotomists, skilled technicians, and expensive, specialized equipment. Cell-free: The use of a cell-free expression system could enable easier-to-read quantitative output that is less susceptible to matrix effects.	8776
Chemically Resolved Microscopy Using Microplasma Discharges Can be operated under ambient temperature and pressure Higher chemical and spatial resolution than currently exists Has the ability to pair mass spectrometry to microscopy	4340
Chemotaxis Bacterial Cell Separation and Preconcentration Ease-to-use – Sensor design is simple and device is self-powered Versatile – Allows detection of: NOx, SOx, H2S, CH4, CO, CO2, H2O, HCL, NH3, PH3, toluene, and mercaptons Reliable – Design allows analysis with low power consumption at high temperatures	6535
Click Hydrogel for Re-Synostosis Therapy Provides a novel delivery vehicle for proteins or other factors for correction of craniosynostosis. Spontaneously polymerizes without producing free radicals. Polymerization can safely take place in-vivo. Allows for tunable mechanical properties and compound release kinetics.	5430
Cluster-Wells: Isolating Aggressive Tumor Cell Clusters for Improved Cancer Diagnosis and Treatment High performing: Demonstrates superior abilities to isolate CTCs without clogging the system or dissociating the clusters Low cost: Shows high potential for large-scale production because it uses simple equipment and a straightforward process Versatile: Isolates CTC clusters of any cancer type and uses hardware that can be modified to accommodate various devices	8203
Compositions & Methods for Using NADH Oxidases Biocatalysis is used in many industries including food, bioenergy, & pharmaceutical. Recycling cofactors is necessary to control costs of biocatalysis reactions. NADH oxidases convert NADH to NAD+, a major cofactor involved in biocatalysis.	4698
Constellation Diagrams to Model Biomolecules’ Electrostatic Properties Low computational cost – reduces algorithm run-time via reduction in complexity of computing molecular electrostatic properties Digitally encoded molecular electrostatic properties – utilizes orthogonal basis functions Visual toolsets- to analyze molecular electrostatic properties and generates 4D plots of molecular electrostatic properties	8245
Core-Shell Nanogel Cellular Delivery Vehicles Delivery of a broad range of various materials to cells Higher payloads and faster and more sustained RNA interference than non-targeted commercial siRNA delivery vehicle Less toxic than commercial liposomal formulations	4480
Customized 3D-Printed Bioresorbable Heart Valves Resorbable, patient-specific heart valves offer great flexibility for treating a wider range of conditions and patients than traditionally manufactured heart valves. Customizable valves potentially decrease complications due to poor fit and the need for reinterventions. Selecting materials for optimal mechanical properties, thermodynamic properties, chemical properties, and surface chemistry and morphology reduces mismatch between device and tissue, potentially improving performance and patient outcomes.	8893
DetectIV Offers Noninvasive Early IV Infiltration and Extravasation Detection DetectIV provides a continuous, noninvasive, and wireless IV infiltration and extravasation detection system. The sensor does not cover the IV site and works well with all skin types—significant improvements over existing detection devices. The device detects infiltrations on average 2 hours ahead of nursing standard of care making it an effective early detection system that prevents extended hospital stays.	7207
Developing Tumor Immune Microenvironments via Engineered Hydrogel Scalable: Enables increased tumor formation rate without sacrificing the dynamic complexity of an in vivo adaptive immune response Improved consistency: Demonstrates consistent induction of tumor growth, latency, and immune infiltration in early analyses of the technology Cost-effective: Eliminates the repetitive processes of conventional methods and leverages inexpensive hydrogel	8785
Devices, Systems and Methods for Ultrafast Optical Applications Enables the design of an ultrafast all-optical shutter technology in the visible spectral range Amplifies the strong and ultrafast nonlinear optical response of noble metal thin films Requires lower pump energies than conventional nonlinear optical materials or devices	6221
Devices, Systems, and Methods for Excavating Cancer Cells Tumors are able to migrate on manufactured fibers or films instead of healthy brain tissue Minimally invasive- the device can be deployed directly or using a catheter The device is size and shape variable- films can range from nano- to micron- scale	5057
Disease Progression Modeling Accurate - Provides continuous time modeling, which is more appropriate for medical data due to patients being monitored at irregular intervals Multipurpose - Could be used for disease staging, characteristic progression pattern discovery, prediction of the future state of disease, fast local progression detection, and to enable understanding of disease progression	6466
Disposable Cassette for Dialysis Efficient- designed to minimize human error and reduces set-up time of dialysis treatment Automated- enables automated dialysis mode selection using radio frequency identification Disposable- eliminates potential contamination in patient treatment	7111
Disposable Impedance Biosensor for Cell Manufacturing Multi-point measurements- provide tempo-spatial profiles of culture attributes and can print a wide range of conductive and insulating materials on both rigid and flexible substrates with non-planar surfaces Wireless - collects the signal wirelessly via printed antennas to simplify the integration to different types of existing bioreactor technologies Safe - system does not apply contact, and minimizes any chance of harm or contamination to affect the cell culture	8270
Drive Belt with Surface Texture to Minimize Vibrations Effective: Demonstrated significant reduction in vibration compared with flat, untextured belt surfaces in preliminary testing Simple: Provides a straightforward and easy-to-implement solution to a widespread problem Economical: Offers a far less expensive means of maintaining the operation of machinery compared with replacing worn belts or employing complex tension systems	8307
Dual Electrode Ultrasonic Transducers Optimized – allows for both transmitting and receiving signals to be optimized Reduced Interference – reduces interference in receiving and transmitting signals to reduce dead zones	3103
Dual-Energy Computed Tomography Through Primary Beam Modulation More affordable than currently available comparable DECT components. Eliminates the need for two scans, resulting in a shorter imaging time and reducing issues associated to patient motion during scans. Compatible with most CT scanners, including cone-beam CT.	7038
Eco-Method Mordant that Improves Natural Dye Adhesion to Synthetic Fabrics Eco-friendly: An improved industrial dyeing process because it reduces excessive heat and water contamination during manufacturing. Wide applicability: Demonstrated to be successful with other materials beyond polyester, including Kevlar and polyacrylonitrile (PAN). Improved quality: Improving commercial dye methods without losing the desired properties of polyester such as flexibility is beneficial to industries like medical supply.	9048
Efficiently Generating Complex Hydrogel Structures for Tissue/Organ-on-a-Chip Models Faster: Reduces preparation time from several hours to minutes Simplified: Generates complex patterns, including perfusable channels, using light-triggered polymerization of synthetic hydrogels and photomasks rather than current equipment-intensive methods that use laser-based patterning or ablation techniques Lowers regulatory burdens: Using synthetic rather than biological matrices simplifies regulatory hurdles, increases reproducibility from batch to batch, and increases tunability of the mechanical and biochemical properties of the matrix	8838, 8839
Electric Field Treatment Creates Safe, Effective Antimicrobial Surfaces Creates safe, effective antimicrobial surfaces via bacteria inactivation without the use of chemicals Targets cell membranes or capsid, is less likely to induce antimicrobial resistance, and should be effective for antibiotic-resistant bacteria Requires very short electrical pulses to achieve effective bacteria inactivation, potentially leading to better antifouling performance	9130
Electronic Immunoassay Using Enzymatic Metallization on Microparticles Lower cost: Replacing fluorescent markers and readout methods with impedance detection has the potential to significantly decrease the cost of the assay. Transportable: Impedance measurements in microfluidics can be made transportable, which can potentially enable point-of-care applications, as electronic elements are more durable than optical elements. Practical: Identification of COVID-19 antibodies in COVID-positive serum samples has already been demonstrated.	8813
Embedded Wireless Temperature Sensor for Orthopedic Implants Utilizes temperature as indication of deep tissue infection Deep tissue measurement vs. only reaching skin surface Non-invasive monitoring	7682
Enabling Rapid Detection of Label-Free RNA for Use in COVID-19 Testing Earlier detection: Identifying the viral components themselves—rather than the body’s reaction to the viral presence (i.e., antibodies)—potentially improves early detection in asymptomatic subjects. Simpler process: Use of minimal reagents and fewer preparatory steps is designed to enable more efficient and facile sample preparation. Avoidance of “wash steps” aims to minimize target loss. Fewer disruptions: Avoiding the use of high-demand supplies (e.g., swabs) and reagents potentially reduces supply-chain and contamination issues.	8669
Equipment-Free Quantification in Point-of-Care Diagnostic Assays Field-deployable robustness: uses reference reactions to accurately measure biomarker levels without expensive or cumbersome equipment Lower cost: quantification does not require expensive technology	7992
Fabrication Approach to Impart Anti-Wetting Properties Does not employ particles to control wetting Approach can be used to modify any material surface Cost-effective	7826
Facilitating Ultrasound Penetration of the Skull for Diagnosis and Treatment Portable: Designed to enable imaging of the brain via small, mobile ultrasound devices, which may offer greater convenience compared with MRI and CT machines Affordable: May be a lower cost modality compared with leading techniques, such as MRI, CT, or positron emission tomography (PET) Robust: Demonstrates energy transmission through the skull on par with that of an aqueous medium in preliminary testing	8340
Fast Microscale Actuators for Probe Microscopy Enables fast and parallel actuation with integrated electrostatic actuators and built-in optical displacement sensors Accurate force measurement with nanometer resolution in parallel single-molecule mechanics experiments Novel FIRAT structures for high speed AFM imaging in liquid environments	3916
Fibrin "Knob" Therapeutics Simple method Robust production Innate therapeutic potential	4021
Fluid Management System for Hemofiltration Compact- size addresses concern of restricted bed-side space Age-friendly- potential use in any age group, from newborns to adults	4209
Fluorescence Microscopy with an Ideal sCMOS Camera Fast – produces fully quantitative sCMOS image restoration up to 100 times faster than the current state-of-the-art Accurate – produces fully quantitative sCMOS image restoration up to two orders of magnitude more accurate than the current state-of-the-art Improved features – allows a broad range of imaging techniques without compromising data reliability	8098
Fluorescent Nanoprobes for Live-Cell RNA Imaging Sensitive — can image single molecules with multiple emission wavelengths Fast — probe is multivalent and bind to RNA in less than 10 minutes Low cost — the alternative dual-label probes are more expensive	4513
Fog-Free GTE Ventilated Face Mask Unique- fog-free patient eye-contact Non-invasive- reduced stress in extended medical staff contact with patients Simple- economical and durable	7138
Foot GO: The Foot Granular Orthosis Customizable: Can easily adjust fit and stiffness Simpler: Has potential to simplify the foot orthosis manufacturing process Re-conformable: Custom fit and stiffness can be readjusted multiple times for changing needs over time	7338
Fourier Light-Field Microscope (FLFM) for Fast, Volumetric, and High-Resolution Imaging of Entire Organoids Cost-efficient and scalable: Is fully adaptable to epifluorescence protocols resulting in a system that is both cost-efficient and highly scalable Fast: Captures fast cellular and tissue dynamic processes in a simultaneous, volumetric manner (e.g., collective cellular responses at sub-second time scales across whole samples) Validated: Responses to extracellular physical cues such as osmotic and mechanical stresses have been recorded using human induced pluripotent stem cell-derived colon organoids (hCOs).	8844
Gaussian Switch Sampling (GauSS) for Training Deep Neural Networks Better analyses: It provides a method to analyze models and their interaction with data. Improved accuracy: By matching or outperforming existing technologies in terms of test accuracy on in-distribution as well as out-of-distribution applications, GauSS is more selective and finds samples that help the network learn as well as remember things previously learned. Versatile: The strategy is based exclusively on learning dynamics and, therefore, can be generalized across networks, data, and training methods.	8757
Generative Causal Explanations for Black-Box Classifiers Increased trust: Has the potential to improve the transparency and fairness of machine learning systems and increase the level of trust users place in their decisions Flexible explanation vocabulary: Provides a rich and flexible vocabulary for explanation that is more expressive than feature selection or saliency map–based methods Deeper insights: Offers visualizations that can be much more descriptive than saliency maps, particularly in vision applications, leading to better user understanding	8507

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