Life Sciences | Page 2 | Technology Licensing

Available Technologies by Category

New Class of Tissue-Targeting Agents Inhibits Fibrosis, Inflammation, and Cancer Growth Potent: Candidates among these agents are 1,000 times more potent than pirfenidone, the standard treatment of IPF. Specific: The compounds may potentially exhibit tissue-targeting properties for sustained levels at disease sites. Minimal toxicity: Enhanced tissue specificity inhibits inflammation and growth of targeted cancer cells while minimizing off-target effects and toxicity.	8374
Bio-SIM-S1: An Automated Biological Sample Aliquoting Processing System Automated: Leverages robotics to eliminate the need for manual aliquoting of biological swab samples Non-contact: Sidesteps the need for human contact with biological samples during the aliquoting process, thereby reducing risk of sample carryover and cross-contamination Economical: Offers the potential to lower the costs associated with biological sample aliquoting and processing, especially for large quantities of samples	3357
Marine Mammal Health Tracking & Informatics Platform Objective health data: Most existing marine mammal health tracking approaches solely consist of subjective observation. This innovation is designed to provide accurate and objective data-driven information to better monitor animal health. Quicker response to problems: This computer-instrumented toy can build a baseline of quantified behavior, enabling animal care staff to see behavioral anomalies that are indicative of health issues and potentially treat the issue more quickly. Simple dashboard interface: In a single glance, the dashboard shows all information a caregiver might need about a given animal—including whether a health issue may be present.	8957
Recombinant Antibodies for Exclusive Detection of Glaucoma-Associated Myocilin Exclusive detection: Unlike current myocilin-directed antibodies that do not differentiate among numerous disease-associated states of the protein (e.g., folded, cleaved, and misfolded myocilin), these reagents only detect folded myocilin Authentic and reproducible: Antibodies are produced using recombinant DNA technology, which enables robust precision sequencing of the reagent and maintains fidelity over time High affinity: Antibodies detect both mouse and human myocilin with well-characterized epitopes and high affinity	8055
Transcatheter Heart Valve with Multi-Arm Mechanism Reduced flow stasis: This mechanism displaces the native valve leaflets away from the THV stent frame, essentially removing its “cover” and allowing blood to move freely through the open stent cells. This can help to significantly reduce flow stasis in the neo-sinus region, thereby reducing thrombus initiation/progression. Prevention of coronary artery obstruction: Coronary artery obstruction following TAVR is a rare but often fatal complication. In rare cases in patients with unusually large native leaflets or small aortic roots, the large leaflets block the flow of blood to the coronary arteries as the new valve’s scaffolding opens. Georgia Tech’s design displaces the native valve leaflets away from the THV stent frame, which can help to reduce this risk. Optimized THV deployment: The innovation offers dual feedback to aid clinicians in determining optimal THV deployment height—a key factor in optimizing patient outcomes. As the device’s “arms” extend against the native vessel wall, they create both tactile feedback during THV positioning as well as visual feedback via fluoroscopy. In addition to deployment height, the multi-arm design supports axial alignment of the THV with respect to the native vessel wall—a factor shown to impact valve performance.	8140
Low-Power Real-Time Ionizing Radiation Detector Sensitive: Detects the charge generated from the interactions of ionizing radiation within matter with a high level of precision and discerns X-ray pulses of varying dose Scalable: Covers a significantly larger detection area than other methods, ranging from 60,000 square micrometers to one square millimeter Responsive: Responds within microseconds and proportionately with the overall radiation dose when exposed to X-rays of varying tube voltage (energy) and tube current (number of particles)	8780
Enabling Rapid Detection of Label-Free RNA for Use in COVID-19 Testing Earlier detection: Identifying the viral components themselves—rather than the body’s reaction to the viral presence (i.e., antibodies)—potentially improves early detection in asymptomatic subjects. Simpler process: Use of minimal reagents and fewer preparatory steps is designed to enable more efficient and facile sample preparation. Avoidance of “wash steps” aims to minimize target loss. Fewer disruptions: Avoiding the use of high-demand supplies (e.g., swabs) and reagents potentially reduces supply-chain and contamination issues.	8669
Gaussian Switch Sampling (GauSS) for Training Deep Neural Networks Better analyses: It provides a method to analyze models and their interaction with data. Improved accuracy: By matching or outperforming existing technologies in terms of test accuracy on in-distribution as well as out-of-distribution applications, GauSS is more selective and finds samples that help the network learn as well as remember things previously learned. Versatile: The strategy is based exclusively on learning dynamics and, therefore, can be generalized across networks, data, and training methods.	8757
Antibodies for Glaucoma Research Precise: Distinguishes between correctly folded and mutated forms from samples, allowing for more precise research and interventions Powerful: Enables a more complete and robust understanding of myocilin antibody targets and their applications in potential glaucoma treatments Enabling: Opens new opportunities for development of pharmaceuticals to treat or prevent damage to the eye caused by glaucoma	8489
A Biological Computing Framework for Living Systems Innovative: Builds on probabilistic computing principles to construct analog biological bits, enabling an entirely new set of logic gates and algorithms and potentially allowing users to solve previously intractable problems Robust: Can sense every extracellular protease encoded in the human genome, for which there is a known peptide substrate, enabling a simple plug-and-play framework for communicating with a variety of biological activities and offering performance competitive with DNA-based computers but with increased processing speed Relevant: Provides a framework based on biological activity and constructed from biological materials, which enables a direct interface with and understanding of living materials and systems	8009
High-Throughput MSC Potency Assay to Bring Feasibility to Immune/Inflammatory Therapeutics Reproducibility: The well-defined cellular environment of the device enables a highly reproducible MSC response not observed in 2D cultures. Scalable: The assay’s simplistic design is amendable to cost-effective scale up. Economical: The low cost of the microfluidic chip and the ease of implementing the assay into existing cell therapy manufacturing practices provide for low costs to enter the market.	8722
Steerable and Flexible Robotic Endoscopic Tool with Instrument-Changing System Flexible: Offers multiple tendon-driven degrees of freedom and is designed to enable the surgeon to avoid obstacles within the workspace Simplifies instrument changes: Includes three instrument stations with a motorized shaft to allow insertion into or retraction from the working channel(s) without leaving the surgical field Reduces procedure time: Demonstrates potential to improve procedure efficiency and patient safety by reducing procedure time	8118
Wearable Health Monitoring Device Improves Data Quality and Accuracy High performance: Captures real-time, real-world data of multiple physiological signals with a significant reduction in MA interference Chest-mounted: Provides more accurate ECG, heart rate, respiratory rate, and activity detection than existing wrist-worn commercial monitors Comfortable: Adheres securely and discretely to the skin using a breathable soft membrane for continuous conformal contact, eliminating excessive sweating and skin irritation	8691
Generative Causal Explanations for Black-Box Classifiers Increased trust: Has the potential to improve the transparency and fairness of machine learning systems and increase the level of trust users place in their decisions Flexible explanation vocabulary: Provides a rich and flexible vocabulary for explanation that is more expressive than feature selection or saliency map–based methods Deeper insights: Offers visualizations that can be much more descriptive than saliency maps, particularly in vision applications, leading to better user understanding	8507
Smart Porous Hydrogels to Increase Cold Supply Chain Efficacy of Biologics and Pharmaceuticals Preservation: With the ability to adjust the pore size of the SMH, researchers may be able to increase the rejection rate of bacteria, thereby protecting the medicine by slowing down biodegradation. Extended use: Preserving the potency of the transported and stored biologic or pharmaceutical should allow for an improved shelf-life (regardless of the cold supply chain) and an increase in the supply accessible to patients. Lower cost: Using Georgia Tech’s SMH for the storage and handling of biologics or pharmaceuticals should minimize the dependence on a cold supply chain, which utilizes freezers that cost between $10,000-$15,000.	8685
Robotically Steerable Guidewire for Improved Vascular Intervention Robotic: Provides operational improvement of guidewire navigation to facilitate catheter placement by employing robotics, while most other commercially available guidewires lack active steering capability Versatile: Controls the guidewire bending angle and also adjusts the bending length of the joint, increasing the capabilities of the guidewire and accommodating varied vasculature geometries Flexible: Can be extended to multiple bending sections and degrees of freedom, in stark contrast to passive guidewires that offer clinicians very limited degrees of freedom	8451
Handheld Breath Collection Device for Detecting Disease Biomarkers Improved diagnosis: Analyzes both the gas and liquid sampled from the patient’s breath for potentially more robust and multifaceted results Enhanced patient experience: Requires a shorter exhalation cycle to get a breath sample, making the test more comfortable for patients Small and portable: Optimizes and miniaturizes the collection process for easy point-of-care applications	8791
Microscale High-Throughput Phenotypic Assay for Fibrosis Powerful: Provides high-throughput image-based analysis of fibrotic processes as well as fibrinolysis Convenient: Combines label-free readouts for fibrin degradation, collagen synthesis, and cell contraction to evaluate fibrotic tissue remodeling Enabling: Opens new opportunities for understanding fibrosis pathogenesis and for evaluating anti-fibrotic therapeutics	8502
A Chip-Scale Linear Ion Trap to Enable Portable Mass Spectrometers Enabling: Can be used in the development of much smaller mass spectrometers than are currently available—from benchtop devices to handheld or even smaller instruments—which would extend their use to applications in which they are not currently cost effective High-performance: Provides better than unit-mass resolution and high detection efficiency, and operates at much higher pressures than larger mass analyzers, as shown during lab-based simulations Multi-modal: Allows for several different modes of operation and enables tandem(MS/MS or MS2) or multi-stage/sequential (MSn) mass spectrometry, greatly improving capability compared with other analyzers	8137
Increasing Medium-Chain Fatty Acid (MCFA) Yield in Bacterial Host with Engineered Enzyme High performance: Increases the yield of MCFAs during chemical and biopolymer synthesis Enabling: Improves the microbial production of chemicals that require the expression of heterologous enzymes Adaptable: Potentially applies to methods of engineering other heterologous enzymes to interact with endogenous proteins in order to produce molecules of interest in a bacterial host	7595
A Biomimetic Nose with Machine Learning for Advanced Threat Detection Enhanced chemical detection: Reduces proximity issues and enhances detection Functional in air and liquid mediums: Can detect single or multiple chemical agents even when the medium contains both a liquid and a gas. An attachment makes it possible to use the device in liquid with air monitoring sensors. Continuous improvement: Uses machine learning algorithms to continually improve agent characterization	7796
Tissue-Selective Anticancer Agents Tissue-targeted activity: Appended macrocyclic skeletons provide selective tissue distribution. Potent: HDAC inhibitors display stronger in vivo anticancer activity against solid tumors compared to current technology. Lower toxicity: Mice in preclinical experiments did not exhibit significant weight loss, pointing to potentially lower toxicity of these compounds.	4195
Heat-Responsive Programmable T-Cells Specific: The remote programmable nature of these T-cells allows them to be selectively activated only in the necessary locations. Protective: This focused, genetically engineered immunotherapy is intended to protect patients from the additional harm of the off-target cell death and unnecessary systemic damage that is more common with oncological therapeutics. Non-invasive: With NIR light’s ability to penetrate into multiple layers of biological tissue and be absorbed by AuNRs, this technology removes the need for a light source in the body to trigger the T-cells.	7422
Self-Titrating Bacterial Protease-Activated Prodrug Effective: Activates an internal dosing mechanism such that the magnitude of an infection locally determines the prodrug dose Robust: Increases the stability of the prodrug form by neutralizing the effective charge of the administered antimicrobial peptide Improves safety: Decreases the potential for off-target effects	8010
Scalable, Low-Cost, Inversion-Free Method of Enabling Automated Underside Cell Seeding Convenient: Eliminates the need for inversion procedures, which tend to be tedious, difficult to automate, and prone to failure—especially for 96-well inserts due to their limited culture area Generalizable: Developed for screenings that focus on the air-blood barrier, but can also be applied to gut, skin, oral mucosa, and other organ systems Scalable: Employs a simple method that is extensible to automated processes for high-throughput drug screenings and pharmacological tests	8677
Rapid Development of SARS-CoV-2 Monoclonal Antibodies Powerful: Demonstrates potential to recognize intact SARS-CoV-2 virions with high affinity Highly efficient: Enables researchers to select pairs of high-affinity antibodies that bind to different receptor sites, maximizing the efficiencies of sandwich-style rapid testing methods Enabling: Furthers the development of neutralizing antibodies that can be used as therapeutic agents, delivered either directly or via mRNA for in situ expression	8487
Skin-Conformal Wearable Stress Monitor Delivers Greater Precision and Continuous, Wireless Monitoring with Comfort and Flexibility All-in-one: The personal adhesive bandage-like single device platform offers wireless, multi-data sensing by simply mounting it on the skin. Disposable: This wearable device is fully disposable after the use and the measured data can be simply sent to the cloud via a tablet or smartphone app. Compact: The unique, thin design of this bioelectric device is one-sixth the volume of current market offerings—weighing less than 7 g, including its rechargeable battery.	8414
Heart Valve Docking System with Precision Positioning and Variable Sizing Versatile: Enables the THV to function in up to 80% of patients while reducing the current risks of complications, such as embolization Precise: Allows a THV to be delivered, positioned, and docked at the junction of the IVC and/or SVC and at the right atrium junction Secure in most any size junction: Compensates for most size differences between the landing site and the size of the THV itself to allow for secure anchoring without the need to create a larger THV	8408
Adaptive Broadband Impedance Matching in Ultrasound Front-End Electronics High performance: Improves power transfer and acoustic reflectivity Flexible: Enables multimodal and tunable operation of CMUTs Efficient: Provides optimal matching for co-design of CMUT electronics	8342
Miniaturized Modular-Array Fluorescence Microscopy Powerful: Offers high fluorescence sensitivity, efficiency, and spatiotemporal resolution (~3 µm and up to 60 Hz) Configurable: Offers compatibility with conventional cell culture assays and physiological imaging, providing accessibility to upright physiological imaging and integration with biochemical sensors under the cell platform Efficient: Provides effective parallelization of multi-site data acquisition	8580
Drive Belt with Surface Texture to Minimize Vibrations Effective: Demonstrated significant reduction in vibration compared with flat, untextured belt surfaces in preliminary testing Simple: Provides a straightforward and easy-to-implement solution to a widespread problem Economical: Offers a far less expensive means of maintaining the operation of machinery compared with replacing worn belts or employing complex tension systems	8307
Advancing Mass Spectrometry with Novel Interface Flexible: Allows for integration with a range of operational modes and analytical workflows for different ESI-MS techniques High performance: Offers enhanced sensitivity and a significantly improved limit of detection Robust and effective: Minimizes charged ion loss and enables sampling of the most analytically “valuable” droplets	4182
Novel, Non-Invasive Stimulation to Control Brain Inflammation and Boost Resilience to Stress Reaches deep brain regions: Drives rhythmic neural activity in deep brain regions that are unreachable by most non-invasive stimulation technology Non-invasive: Uses only lights and sound with precise timing and control Fast response: Effects are seen in 5 to 30 minutes rather than hours	7773, 7832, 8745
Integrating Electrical Sensors into Soft-Lithography Microfluidic Devices Sophisticated: Advances the integration of electrical sensors on microfluidic devices with a simple, approachable solution Sensitive: Demonstrates a higher signal sensitivity than electrodes in a typical coplanar arrangement Adaptable: Allows for greater layout flexibility because of its straightforward fabrication process	7769
Microfluidic CODES with Innovative Machine-Learning Analysis Scalable: Set-up allows for the integration of multiple microfluidic devices to increase throughput volume. Versatile: Machine learning analysis can be applied to other microfluidic devices integrated with the same Coulter sensor network. Pragmatic: This innovation improves the capabilities of lab-on-a-chip systems to provide an affordable solution for low-resource settings.	7107, 8032
Utilizing Impedance Spectroscopy for Advanced Characterization of Particles Comprehensive: Simultaneously measures both spatial and dielectric properties of particles Streamlined: Helps resolve signal interference from coincident cells—a challenge of other assessment techniques Precise: Offers complex impedance as a new level of particle feature assessment, integrating it with other measurements such as elasticity and size for more predictive analyses	8049
All-Electronic Immunophenotyping Device for Point-of-Care Testing Convenient: Provides an all-electronic immunophenotyping process with straightforward equipment and techniques Low cost: Performs sophisticated, multistep analyses in a system that is affordable enough for point-of-care settings Flexible: Allows for the easy immobilization of multiple antibodies in the device—a shortcoming of current systems	8045, 8047
Scalable Microfluidic Device with Multiple Constriction Channels for High-Throughput Mechanophenotyping High throughput: Addresses the low-throughput challenges of other similar technologies by handling a sample volume near that of a Coulter counter Low cost: Eliminates the need for costly equipment, highly trained personnel, and long processing times that come with other measuring processes Scalable: Uses a frequency division scheme so that multiple copies of the system can operate concurrently	8031
Measuring Surface Antigen Expression via Microflow Cytometry Portable: This innovation uses a disposable, handheld device without bulky or costly equipment, which is expected to be especially useful in low-resource settings. Simple: It is designed to achieve results similar to those from a commercial flow cytometer but without requiring initial purification. Recoverable samples: Unlike commercial systems, the analyzed sample can be recovered for further tests at the end of the analysis.	7913, 8048
Innovative Ion Mobility Spectrometry with Open-Air Assembly Protective: Potentially helps protect the technician against contact with ionic hazards Rapid: Separates ions through fast detection of differences in their mass, charge, and cross-section Convenient: Leverages an open-air arrangement that significantly reduces time for experiment setup and sample preparation	4885

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