Life Sciences | Technology Licensing

Available Technologies by Category

2D Array Device Simple – does not require microstructure fabrication or periphery equipment, such as pressure-driven pumps to operate Unique – loading method enables rapid sample loading and high-percentage sample isolation simultaneously Cheaper – improvements in efficiency and robustness reduce complexity and overhead expenses	8253
3D Light-Field Endoscopy for High-Precision Microsurgery Enhanced control and safety: Real time visual navigation enhances guidance and intervention in complex microenvironments, maintaining high spatial resolution while providing quantitative depth information Comfortable: System does not require 3D glasses that can cause physician dizziness or headaches after long periods of use Streamlined: Technique eliminates the need for other imaging procedures such as micro-CT or MRI to quantify the 3D morphology of tissue	8848
3D Light-Field Endoscopy Using a Gradient Index Lens Array Measurements: system achieves 'true quantitative' 3D information Imaging and visualization: system brings a great potential for fast 3D quantitative imaging, visualization, and synthesis of the focal stacks Material: method is glass-free	8283
3D Optical Microscope Imaging System Versatile — Analyze several small scale samples Easy-to-use — Decoding of the 3D information is straightforward and involves only 2D digital image correlation (2D-DIC) calculations or other types of 2D displacement analysis Accurate — High measurement accuracy (sub-pixel accuracy of ~10)	6136
3D Printed Auxetic Scaffolds for Tissue Engineering Faster cell growth rate- decreases average cell age in the finished product and increases vitality Affordable and timely approach for regenerating tissues and replacing native tissues Continuous entry and circulation of nutrients results in less variability between cells	7335
3D Printed Device for Tumor Cell Diagnostics Minimally invasive – potentially eliminates the need for invasive serial biopsies Cheaper – simple manufacturing process Disposable - size and materials allow for easy disposal	7346
3D Printed Tissue-Mimicking Phantoms Fabricates patient-specific tissue-mimicking phantoms with accurate biomechanical properties, in addition to accurate geometric properties Associates biomechanical properties with gender, age, and other physiological/pathological conditions of the patient	7339
A Biodegradable Polymer for Medical Applications Adaptive and applicable – mechanical properties can be tailored to the desired medical application Controlled biodegradation- biodegradation profile is easily adjustable	5121
A Biological Computing Framework for Living Systems Innovative: Builds on probabilistic computing principles to construct analog biological bits, enabling an entirely new set of logic gates and algorithms and potentially allowing users to solve previously intractable problems Robust: Can sense every extracellular protease encoded in the human genome, for which there is a known peptide substrate, enabling a simple plug-and-play framework for communicating with a variety of biological activities and offering performance competitive with DNA-based computers but with increased processing speed Relevant: Provides a framework based on biological activity and constructed from biological materials, which enables a direct interface with and understanding of living materials and systems	8009
A Biomimetic Nose with Machine Learning for Advanced Threat Detection Enhanced chemical detection: Reduces proximity issues and enhances detection Functional in air and liquid mediums: Can detect single or multiple chemical agents even when the medium contains both a liquid and a gas. An attachment makes it possible to use the device in liquid with air monitoring sensors. Continuous improvement: Uses machine learning algorithms to continually improve agent characterization	7796
A Chip-Scale Linear Ion Trap to Enable Portable Mass Spectrometers Enabling: Can be used in the development of much smaller mass spectrometers than are currently available—from benchtop devices to handheld or even smaller instruments—which would extend their use to applications in which they are not currently cost effective High-performance: Provides better than unit-mass resolution and high detection efficiency, and operates at much higher pressures than larger mass analyzers, as shown during lab-based simulations Multi-modal: Allows for several different modes of operation and enables tandem(MS/MS or MS2) or multi-stage/sequential (MSn) mass spectrometry, greatly improving capability compared with other analyzers	8137
A Method for Exhaustive CRISPR Off-Target Analysis Provides exhaustive genomic searches for off-target sites due to mismatches, deletions, and insertions Provides primers for experimental validation of predicted off-target sites Facilitates experimental testing using assays or deep sequencing of potential off-target sites given in the output	6478
A Partial-Hand Prosthesis Simulator Specific: Designed to maintain limb length by placing artificial fingers in positions similar to where they would be in an intact hand performing grasping actions (rather than extending the length of the limb as many prostheses do) User friendly: Features rubber-capped fingertips that may provide a more lifelike representation of grasp and enhance usability Nuanced: Designed to limit tactile sensation and feedback from immobilized fingers, which may allow better evaluation of how the device is functioning for the patient in comparison to an actual prosthesis	8534
A Screening Method to Detect Ovarian Cancer Early stage detection Highly accurate Minimally invasive	7028
A Semiconductor Particle Detector Based on Work Function Modulation Small: Can be used as a portable radiation detector Versatile: Can be implemented in current particle detectors for accuracy testing and experimental verification Scalable: Offers the potential to be used in creating an array of devices for implementation in larger research experiments	8410
A Technique for Integrating Photographs for Medical Imaging Examinations Prevents the application of incorrect patient identification at the time of medical image generation Allows the correlation of serial imaging studies by ensuring that all studies are from the same patient Avoids the generation of incorrect reports	6402
Adaptive Broadband Impedance Matching in Ultrasound Front-End Electronics High performance: Improves power transfer and acoustic reflectivity Flexible: Enables multimodal and tunable operation of CMUTs Efficient: Provides optimal matching for co-design of CMUT electronics	8342
Advanced Manufacturing of Biodegradable Shape Memory Polymers Increases In Vivo Success Faster healing: Improvements catalyze the regeneration of tissue for a faster recovery Increased efficacy: Decreases the likelihood of rejection because the polymers are manufactured in such a way to increase tissue ingrowth and cell attachment Reduced healthcare resource utilization: When initial implantation is successful, it reduces the need for secondary procedures or advanced clinical care for infection	8658
Advancing Mass Spectrometry with Novel Interface Flexible: Allows for integration with a range of operational modes and analytical workflows for different ESI-MS techniques High performance: Offers enhanced sensitivity and a significantly improved limit of detection Robust and effective: Minimizes charged ion loss and enables sampling of the most analytically “valuable” droplets	4182
AFM Cantilevers for Operation in Air and Immersion Efficient — enables fast actuation with integrated electrostatic actuators Accuracy — accurate force measurements with nanoscale lateral resolution Improved speed — improvement for both speed of actuation and accuracy of detection	3629
Airy-beam Tomographic Microscopy for Biological Imaging Streamlined: Offers a scan-free method of obtaining 3D-resolution images Volumetric imaging: Generates and resolves images of tissues and cells in the 3D space High resolution and image depth: Provides 3D diffraction-limited resolution	8381
All-Electronic Immunophenotyping Device for Point-of-Care Testing Convenient: Provides an all-electronic immunophenotyping process with straightforward equipment and techniques Low cost: Performs sophisticated, multistep analyses in a system that is affordable enough for point-of-care settings Flexible: Allows for the easy immobilization of multiple antibodies in the device—a shortcoming of current systems	8045, 8047
Alveolar Breath Separation and Collection Device Simple: this device has fewer components than prior devices Inexpensive: this device is less expensive than previous devices due to its simpler design	4734
Annuloplasty Ring & Methods for Tricuspid Valve Repair Specificity- aligns with specific landmarks only found on the tricuspid annulus Unique- attains an anterior, posterior, and septal segment that conform to the anterior, posterior, and septal sections of the native tricuspid annulus Regulatory- adjustable annuloplasty ring, which facilitates independent control over individual leaflets.	4240
Antibodies for Glaucoma Research Precise: Distinguishes between correctly folded and mutated forms from samples, allowing for more precise research and interventions Powerful: Enables a more complete and robust understanding of myocilin antibody targets and their applications in potential glaucoma treatments Enabling: Opens new opportunities for development of pharmaceuticals to treat or prevent damage to the eye caused by glaucoma	8489
Antibody Coated Nanoparticle Vaccines Enhance vaccine immunogenicity Prolong vaccine protection Reduce safety risks associated with pathogen-derived vaccine adjuvants	7403
Antifolate Compound as Multi-Drug Resistant Pathogens Novel structure with high binding affinity for DHFR Demonstrated growth inhibition of numerous pathogens Demonstrated antibacterial activity for mulit-drug resistant strains of E. coli, methicillin-resistant S. aureus (MRSA), vancomycin-resistant E. faecalis & antifungal activity against amphotericin–resistant Candida albicans	6296
Aptamer-Driven Gene Targeting Apatamers have unique secondary structure, allowing them to bind with high specificity and affinity to a specific target Utilizes intrinsic double stranded DNA break (DSB) and repair system, enabling targeted delivery of exogenous DNA in all eukaryotic cell types AGT development could lead to enhancement of gene editing technologies and ultimately disease-targeted therapy	6757
Artificial Neural Network (ANN) with Unique Input Design That Significantly Reduces Computational Costs of Complex Engineering Systems Neural network’s novel input can utilize first-order schemes and local patches and allows for discontinuities to be reflected accurately and with greater resolution than existing products. This adaptable ANN can be adopted by commercial and scientific research as a stand-alone solution or in conjunction with existing software. Lower costs for running complex and repetitive computations can be achieved by implementing this neural network with an input system that processes low-cost numerical solution patches arising from two or more converging solutions.	8963
Assessment of Soluble Cancer Biomarkers for Focused Ultrasound Therapy Simple: Avoids reliance on magnetic resonance imaging (MRI)-based methods of monitoring and optimizing FUS therapy Safe: Relies on a small amount of fluid collected before/after FUS-targeted drug delivery Robust: Enables a range of new therapeutic interventions for cancerous tumors as well as both delivery and monitoring/optimizing of those therapies	8473
Assistive Stairs Utilizing Energy-Recycling Technology ERAS are the only energy-recycling device tailored for assistance during stair movement. The modular design of ERAS allow for quick and easy installation (and removal, if necessary) on top of an existing staircase without expensive remodeling. The low-cost and low-power design allow ERAS to be more affordable and practical to people with limited financial resources.	7596
Automated Bioreactor Sampling System Can Eliminate Cross-Contamination of Samples Automated bioreactor sampling system maintains sample integrity by changing the syringe between samples In addition to savings related to reduced cross-contamination, automated sampling can further lower costs by reducing hands-on time and speeding sampling. Flexible platform can be used with any type of collected sample.	8886
Automated Medical Image Interpretation for Tissue Segmentation Increased accuracy: Computer processing removes the need to manually interpret boundaries Fast: The algorithm is extremely rapid, repeatable, and accurate Versatile: Programs can be implemented in assembly or machine language	5107
Bio-SIM-S1: An Automated Biological Sample Aliquoting Processing System Automated: Leverages robotics to eliminate the need for manual aliquoting of biological swab samples Non-contact: Sidesteps the need for human contact with biological samples during the aliquoting process, thereby reducing risk of sample carryover and cross-contamination Economical: Offers the potential to lower the costs associated with biological sample aliquoting and processing, especially for large quantities of samples	3357
Biodegradable Shape Memory Polymer for 3D-Printed Tissue and Biomedical Devices New synthesis reaction produces novel biomaterials for soft tissue treatment combines shape memory and biodegradability with custom 3D printing for patient-specific, minimally invasive solutions Customizable to patient needs by varying the formulation and molecular architecture to alter the mechanical properties Improves safety and efficacy by providing a much-needed middle range to existing “too hard/too soft” tissue repair options, while also being biodegradable and bioresorbable	8655
Biomolecular Coating for Implants Simple, one-step surface modification without chemical cross-linking agents Modification at the time of surgery in the operation room Straight forward sterilization	3967
Biopolymer Fabricated Materials for Biomaterials Novelty – first technology that enables the formation of biopolymer brushes at interfaces of any thickness Incredibly biocompatible – hyaluronan has many salient features such as being non-fouling, non-immunogenic, and viscoelastic that make it a common polymer used in biomedical applications Potential for regenerative technology – further applied in regenerative interface technology research	7535
BrainBraille Increased information bandwidth and speed for BCI devices Rapid learning of motions and associated meanings Enhanced accuracy	8088
Cancer Diagnosis Using Nanotechnology Can be used with a simple microscope More sensitive and cost-effective Non-toxic	3424
Capillary Flow Control in Lateral Flow Assays (LFAs) via Delaminating Timers ASSURED: LFAs readily satisfy the majority of the ASSURED (affordable, sensitive, specific, user-friendly, rapid and robust, equipment-free, and deliverable to end-users) criteria reported by the World Health Organization to establish capabilities of POC devices. Agile: The addition of timers to LFAs provides an opportunity to develop more complex multi-step testing, as well as additional benefits such as built-in signal amplification and POC DNA extraction and purification. Automated: The ability to sequentially deliver different reagents into a reaction via programmable timers imprinted on paper makes it possible to automate multi-step assays that otherwise could only be performed in laboratories or with manual intervention.	8462, 8634

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