Life Sciences | Technology Licensing

Available Technologies by Category

Paper-Based Multi-Well Depletion Enzyme-Linked Immunosorbent Assay (ELISA) Enables Point-of-Care (POC) Testing Paper-based lateral flow assay automatically performs multi-well ELISA testing for POC titer measurements. Simplifies ELISA testing by eliminating the need for centralized laboratories staffed with trained personnel who perform multiple steps in a specific sequence to execute the assay workflow. Transforms a variety of ELISA-based tests into single-use, disposable dipstick tests to be used at the point of care or at home.	9124
Electric Field Treatment Creates Safe, Effective Antimicrobial Surfaces Creates safe, effective antimicrobial surfaces via bacteria inactivation without the use of chemicals Targets cell membranes or capsid, is less likely to induce antimicrobial resistance, and should be effective for antibiotic-resistant bacteria Requires very short electrical pulses to achieve effective bacteria inactivation, potentially leading to better antifouling performance	9130
Customized 3D-Printed Bioresorbable Heart Valves Resorbable, patient-specific heart valves offer great flexibility for treating a wider range of conditions and patients than traditionally manufactured heart valves. Customizable valves potentially decrease complications due to poor fit and the need for reinterventions. Selecting materials for optimal mechanical properties, thermodynamic properties, chemical properties, and surface chemistry and morphology reduces mismatch between device and tissue, potentially improving performance and patient outcomes.	8893
Parametric Resonance Approach for Efficient, Versatile Acoustic Power Transfer for Implantable/Wearable Devices, Sensing, and Communications New class of transducers utilizes parametric resonance to convert acoustic energy from an ultrasonic source to a sustained electrical signal. Technology powers implantable biomedical devices, small wearable sensors, and other wireless charging applications. Simple yet robust generation of stable electromechanical frequency combs is also possible in both air and liquid environments using a capacitive micro-resonator array.	7635, 9075
Artificial Neural Network (ANN) with Unique Input Design That Significantly Reduces Computational Costs of Complex Engineering Systems Neural network’s novel input can utilize first-order schemes and local patches and allows for discontinuities to be reflected accurately and with greater resolution than existing products. This adaptable ANN can be adopted by commercial and scientific research as a stand-alone solution or in conjunction with existing software. Lower costs for running complex and repetitive computations can be achieved by implementing this neural network with an input system that processes low-cost numerical solution patches arising from two or more converging solutions.	8963
Melting Microneedle Patches Extend Drug Delivery Applications, Simplify Manufacturing, and Reduce Costs Melting microneedles enable dispersion of both poorly soluble and water-soluble drugs, which eliminates the need for solvents for improved stabilization and broader applications. Melting microneedles shorten manufacturing and drying time, eliminate the need to maintain a cold chain for storage and transportation, and reduce the ultimate cost of the microneedle patch. The safe suppository bases are inexpensive and enable control of the drug release timing.	8904
Quantitative, Performance-Driven Framework for Optimal Desalination Architectures and Energy Subsystems Incorporate and simultaneously compare attributes of multiple types of both desalting systems and energy subsystems for optimal system architectures Assess parameters that impact overall cost to discover complete architectures that would not have been discoverable using traditional methods. Focus on renewable energy subsystems such as solar, wind, geothermal, hydroelectric, and others to create complete desalination architectures that are cleaner and more water efficient than their conventional counterparts.	9055
Novel Nanocarriers Strengthen Therapeutic Delivery, Improves Efficacy Greater therapeutic effectiveness is due to the synergistic work of multiple therapeutic agents (hydrophobic/hydrophilic charged) that can be delivered via this dual-loaded biomaterial. The risk of immunotoxicity to a vaccine is reduced because an adjuvant, which can induce the body’s anti-inflammatory immune response, may be loaded and simultaneously delivered with the vaccine. The novel nanocarrier has broad market application since it can deliver vaccines, gene therapy, small molecule drugs, and even contrast agents.	8988
Automated Bioreactor Sampling System Can Eliminate Cross-Contamination of Samples Automated bioreactor sampling system maintains sample integrity by changing the syringe between samples In addition to savings related to reduced cross-contamination, automated sampling can further lower costs by reducing hands-on time and speeding sampling. Flexible platform can be used with any type of collected sample.	8886
Efficiently Generating Complex Hydrogel Structures for Tissue/Organ-on-a-Chip Models Faster: Reduces preparation time from several hours to minutes Simplified: Generates complex patterns, including perfusable channels, using light-triggered polymerization of synthetic hydrogels and photomasks rather than current equipment-intensive methods that use laser-based patterning or ablation techniques Lowers regulatory burdens: Using synthetic rather than biological matrices simplifies regulatory hurdles, increases reproducibility from batch to batch, and increases tunability of the mechanical and biochemical properties of the matrix	8838, 8839
Electronic Immunoassay Using Enzymatic Metallization on Microparticles Lower cost: Replacing fluorescent markers and readout methods with impedance detection has the potential to significantly decrease the cost of the assay. Transportable: Impedance measurements in microfluidics can be made transportable, which can potentially enable point-of-care applications, as electronic elements are more durable than optical elements. Practical: Identification of COVID-19 antibodies in COVID-positive serum samples has already been demonstrated.	8813
patcherBotPHARMA Automated Intracellular Pharmacological Electrophysiology Robot Increased efficiency: Autonomous operation ensures accurate placement of components and creates high success rates for experiment completion. Decreased human effort: Performs typical ligand-gated ionotropic receptor experimentation protocols autonomously for up to a tenfold reduction in operator interaction time over the duration of the experiment Higher experiment yield: Rapidly replicates previous datasets, reducing the time to produce an 8-point concentration response curve from weeks of recording to ~13 hours of recording	8717
Wearable Ocular Electronics with Virtual Reality Solution for Effective Home-Based Vision Therapy The first fully portable and wireless ocular electronic system in a VR environment provides an effective, home-based visual therapy program. The integrated wearable system has a data classification algorithm to provide high-fidelity, real-time detection of eye vergence to treat eye disorders. Running a VR system on a smartphone can create “virtual therapies” that can be used anywhere anytime.	7916
Simulated Synovial Fluid Offers Potential for Effective Treatment of Knee Osteoarthritis Osteoarthritis (OA)-simulated synovial fluid (simSF) provides the opportunity to evaluate how different cell therapies respond to an OA-like environment. By analyzing OA patient-derived synovial fluid (pdSF) and developing potency assays, researchers created a simSF comparable to pdSF that overcomes patient variability. The simSF allows for the investigation of OA biology with greater reproducibility of predictive outcomes and could advance effective treatment of knee OA.	8956
“Smart” Feedback-Controlled Bioreactor Platform Enables Consistent High-Yield and High-Quality MSC Products Scaled-down feedback-controlled hollow fiber-based bioreactor enables identifying the critical quality attributes and critical process parameters for high-quantity and high-quality hCT-MSCs for ideal cell growth and efficacy Provides the controls to maintain optimum conditions and improve expansion yield and cell viability System can be adapted and applied to industrial cell therapy manufacturing and can enable high-yield and high-quality products while minimizing variabilities	8887
Reducing Intraocular Pressure in Glaucoma Patients Without Drugs or Surgery via a Simple Hydrogel Injection Hydrogel injections alleviate elevated intraocular pressure (IOP) with fast results and extended impact. Surgery-free approach eliminates the risk of tissue damage caused by a surgical incision or laser application. Simplified and effective treatment process from standard daily drug intake to a brief office visit only once every 4-6 months.	8467
DetectIV Offers Noninvasive Early IV Infiltration and Extravasation Detection DetectIV provides a continuous, noninvasive, and wireless IV infiltration and extravasation detection system. The sensor does not cover the IV site and works well with all skin types—significant improvements over existing detection devices. The device detects infiltrations on average 2 hours ahead of nursing standard of care making it an effective early detection system that prevents extended hospital stays.	7207
Biodegradable Shape Memory Polymer for 3D-Printed Tissue and Biomedical Devices New synthesis reaction produces novel biomaterials for soft tissue treatment combines shape memory and biodegradability with custom 3D printing for patient-specific, minimally invasive solutions Customizable to patient needs by varying the formulation and molecular architecture to alter the mechanical properties Improves safety and efficacy by providing a much-needed middle range to existing “too hard/too soft” tissue repair options, while also being biodegradable and bioresorbable	8655
Synthetic Hydrogel for Satellite Cell Delivery in Dystrophic Skeletal Muscle Addresses the critical need for a viable treatment for deterioration of the diaphragm, which is a leading cause of respiratory failure and death in Duchenne Muscular Dystrophy patients Engineered hydrogels comprised of synthetic polymers and peptides are designed to enable successful muscle satellite cell (MuSC) transplantation to the diaphragm or other dystrophic skeletal muscle tissue Shown to support MuSC survival, proliferation, and differentiation, which can enable restoration of dystrophin – a protein absent in DMD and critical to strengthening and repairing muscle fibers	7841
Microrobots for Neurosurgery Applications Minimally invasive: Significantly reduces invasiveness of procedures in comparison to current macroscale, neurosurgical robots Precise control: Uses 3D position data of the microrobots on the brain surface in a closed-loop system to adjust the magnetic field parameters (i.e., magnitude, frequency, phase, and direct current [DC] offset of each coil) as well as the forces the robots exert to the biopsy tissue Facilitates movement: Employs microfabricated shapes that dictate the microrobot's movements, limits their contact with the brain surface to reduce adhesion, and may also provide a means for the robot to propel itself in fluid	8749
Synthetic Hydrogels for Human Organoid (HO) Generation and Transplantation Synthetic hydrogel exhibits high cytocompatibility and minimal toxicity and inflammation in vivo for improved human organoid viability Injectable delivery vehicle supports localized HO engraftment in mucosal wounds to potentially enhance wound closure and repair Modular design and delivery via endoscopic techniques enables the translational potential of this delivery platform for regenerative medicine and overcomes limitations associated with the use of commercially available matrices for hPSC-based organoid technologies	7536
Hybrid Molecular Catalysts: A New Blueprint for Catalyst Design, Preparation, and Testing Attachment of molecular catalysts to solid supports can lead to new reactivity not seen under homogeneous conditions At an optimal atomic layer deposition (ALD) layer thickness, the molecular catalyst remains highly active while still being resistant to surface detachment and subsequent deactivation Catalyst separation and recovery achieved via a simple filtering and washing process rather than energy- and time-intensive distillation or re-crystallization processes In addition to the simple filter-and-wash process mentioned above, encapsulation requires only about 10 reaction cycles, making this process technologically and economically viable for large-scale manufacturing	8537
Eco-Method Mordant that Improves Natural Dye Adhesion to Synthetic Fabrics Eco-friendly: An improved industrial dyeing process because it reduces excessive heat and water contamination during manufacturing. Wide applicability: Demonstrated to be successful with other materials beyond polyester, including Kevlar and polyacrylonitrile (PAN). Improved quality: Improving commercial dye methods without losing the desired properties of polyester such as flexibility is beneficial to industries like medical supply.	9048
Advanced Manufacturing of Biodegradable Shape Memory Polymers Increases In Vivo Success Faster healing: Improvements catalyze the regeneration of tissue for a faster recovery Increased efficacy: Decreases the likelihood of rejection because the polymers are manufactured in such a way to increase tissue ingrowth and cell attachment Reduced healthcare resource utilization: When initial implantation is successful, it reduces the need for secondary procedures or advanced clinical care for infection	8658
Hydrogels for Controlled Delivery of Lysostaphin to Treat Staphylococcus aureus Infections Injectable (or surgically applied) hydrogel formulation conforms and adheres to the fracture and surrounding tissue, ensuring efficient, local delivery of lysostaphin Localized treatments enable higher relative doses to be given at the site of infection, and enhanced stability from the hydrogel carrier may reduce the number of overall doses needed Tunable nature of the material provides control over the amount and time over which lysostaphin is delivered	7729
Innovative Polymeric Bipolar Membrane Design Provides Wide Industrial Applications This innovative bipolar membrane design dissociates water at a low voltage and provides a tunable membrane with a green method for large-scale manufacturing. Polyvinyl alcohol-based bipolar membrane designs reduce energy costs, maintenance, and toxic chemical usage. This polymeric bipolar membrane is widely applicable across industries, including fuel cells, hydrogen production, carbon capture/conversion, wastewater treatment, and battery-based technologies.	9044
Scalable Manufacturing Approach of Graded Polymer Thin Film Has Potential for Widespread Use Combines slot die coating with a custom roll-to-roll imaging system to allow for efficient, rapid, and scalable fabrication of high-quality gradient thin films. An improved manufacturing process over existing techniques because it uses broad material combinations and yields higher quality patterned thin films. Incorporates multiple materials to increase the application of patterned thin films across industries, including microelectronics, energy technologies, and environmental systems.	8994
Smart, Wireless, Bioelectronic Pacifier for Real-Time Continuous Salivary Electrolyte Monitoring in Infants Smart pacifier offers wireless, real-time, continuous detection of sodium and potassium levels in infants. This totally non-invasive monitoring pacifier eliminates the need for blood draws, which can only be done three times each day, and is designed to provide non-invasive neonatal health monitoring. Microfluidic channels are designed to efficiently pump optimum quantities and concentration of viscous saliva to the sensor area for quick measurement and to eliminate the need to induce salivary stimulation.	8942
Quantitative, Multiplexed Electronic Detection of COVID-19 Biomarkers Direct electronic detection: This innovation provides direct detection of biomarkers as a simple electronic readout without the use of any intermediate optics. Multiplexed: The device can simultaneously detect multiple biomarkers (e.g., a four-plex chip to detect IgG and IgM antibodies against spike or nucleocapsid antigens). Portable: A handheld, cellphone-interfaced reader is designed to enable detection and monitoring of diseases in remote areas for sensitive yet inexpensive point-of-care use.	8814
Developing Tumor Immune Microenvironments via Engineered Hydrogel Scalable: Enables increased tumor formation rate without sacrificing the dynamic complexity of an in vivo adaptive immune response Improved consistency: Demonstrates consistent induction of tumor growth, latency, and immune infiltration in early analyses of the technology Cost-effective: Eliminates the repetitive processes of conventional methods and leverages inexpensive hydrogel	8785
Capillary Flow Control in Lateral Flow Assays (LFAs) via Delaminating Timers ASSURED: LFAs readily satisfy the majority of the ASSURED (affordable, sensitive, specific, user-friendly, rapid and robust, equipment-free, and deliverable to end-users) criteria reported by the World Health Organization to establish capabilities of POC devices. Agile: The addition of timers to LFAs provides an opportunity to develop more complex multi-step testing, as well as additional benefits such as built-in signal amplification and POC DNA extraction and purification. Automated: The ability to sequentially deliver different reagents into a reaction via programmable timers imprinted on paper makes it possible to automate multi-step assays that otherwise could only be performed in laboratories or with manual intervention.	8462, 8634
Recirculation System for Aerosol Collectors Maximizes Particle Concentration for Improved Pathogen Detection Enhanced detection: Continuously recirculated collection buffer increases the concentration of targeted particles collected and improves detection of pathogens Increased sampled air volume: Recirculating the buffer enables running the system for longer periods of time and with larger volumes of air to improve pathogen detection in entire buildings Increased control: Users have active control of the volume of fluid introduced during collection via the system’s recharge pump	8903
3D Light-Field Endoscopy for High-Precision Microsurgery Enhanced control and safety: Real time visual navigation enhances guidance and intervention in complex microenvironments, maintaining high spatial resolution while providing quantitative depth information Comfortable: System does not require 3D glasses that can cause physician dizziness or headaches after long periods of use Streamlined: Technique eliminates the need for other imaging procedures such as micro-CT or MRI to quantify the 3D morphology of tissue	8848
Cluster-Wells: Isolating Aggressive Tumor Cell Clusters for Improved Cancer Diagnosis and Treatment High performing: Demonstrates superior abilities to isolate CTCs without clogging the system or dissociating the clusters Low cost: Shows high potential for large-scale production because it uses simple equipment and a straightforward process Versatile: Isolates CTC clusters of any cancer type and uses hardware that can be modified to accommodate various devices	8203
Fourier Light-Field Microscope (FLFM) for Fast, Volumetric, and High-Resolution Imaging of Entire Organoids Cost-efficient and scalable: Is fully adaptable to epifluorescence protocols resulting in a system that is both cost-efficient and highly scalable Fast: Captures fast cellular and tissue dynamic processes in a simultaneous, volumetric manner (e.g., collective cellular responses at sub-second time scales across whole samples) Validated: Responses to extracellular physical cues such as osmotic and mechanical stresses have been recorded using human induced pluripotent stem cell-derived colon organoids (hCOs).	8844
TabAccess: A Wireless Controller for Tablet Accessibility Enabling: Provides an alternative interface to touchscreen-based devices for people with limited fine motor control, potentially enabling them to interact with applications that could improve their quality of life or even create employment opportunities Reconfigurable: Sensor modules can be interconnected as well as separated and mounted anywhere (e.g., on the human body or on a table, floor, wheelchair, etc.), enabling adaptation of the device based on the capability, range of access, and the individual’s range of motion. Adjustable: Uses an adjustable Velcro strap so one size fits the majority of forearms	5946
Cell-free Biosensors to Detect Creatinine, Creatine, and Sarcosine Portable: This technology demonstrates the potential to develop point-of-care screening and monitoring, which is essential to expanding access to care worldwide, including to low- and middle-income countries. Inexpensive: CFE-based biosensors can cost as little as a few cents per test and could provide a low-cost alternative to current renal function monitoring and diagnosis, which currently involves laboratory visits, trained phlebotomists, skilled technicians, and expensive, specialized equipment. Cell-free: The use of a cell-free expression system could enable easier-to-read quantitative output that is less susceptible to matrix effects.	8776
New Methods for Skin Tissue Engineering: Textile-Based Sandwich Scaffold and CNT-based Electrospun Polymer Composite Yarns Biocompatible: Exhibits good biocompatibility of the yarns fabricated using a wet electrospinning technique (results shown within a limited range of CNT concentration in the bath) Purposeful: Mimics the strain-stiffening behavior of human tissue, unlike other scaffolds that exhibit strain-softening of their synthetic materials Demonstrated: Exhibits the ability to guide cell anisotropic arrangement as well as support cell proliferation and infiltration in in vitro biological tests	8751, 8752
Small Molecule Glycosylated Histone Deacetylase Inhibitors (HDACi) Targeted: The compounds were particularly cytotoxic to liver or hepatocellular cancer cells (HCC) during in vivo murine model laboratory studies. Enhanced potency: The compounds’ hepatocellular carcinoma selectivity observed in laboratory studies potentially increases their efficacy on liver cancer and possibly other cancers. Many formulations: A number of formulation methods are potentially available, including tablets, beads, granules, microparticle, or nanoparticles that provide a variety of drug release profiles.	8373
Wearable Device for Evaluating Post-Injury Ankle Health During Ambulation Better decisions: Helps clinicians more easily determine the best course for ankle rehabilitation and improves compliance with physical therapy Faster recovery: Enables improved rehabilitation guidance based on collected telehealth data that may speed the time to recovery Fewer re-injuries: Supports clinicians in making better decisions regarding appropriate activity levels and readiness to return to activities to avoid re-injury	8513

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